期刊
GENES & DEVELOPMENT
卷 27, 期 10, 页码 1073-1078出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.220178.113
关键词
Hfq; CsrA; CsrB; PGA; c-di-GMP
资金
- Deutschen Forschungsgemeinschaft (DFG)
- Bundesministerien fur Bildung und Forschung (BMBF)
- Bavarian BioSysNet program
- EMBO long-term fellowship
The abundant RNA-binding proteins CsrA and Hfq each impact bacterial physiology by working in conjunction with small RNAs to control large post-transcriptional regulons. The small RNAs involved were considered mechanistically distinct, regulating mRNAs either directly through Hfq-mediated base-pairing or indirectly by sequestering the global translational repressor CsrA. In this issue of Genes & Development, Jorgensen and colleagues (pp. 1132-1145) blur these distinctions with a dualmechanism small RNA that acts through both Hfq and CsrA to regulate the formation of bacterial biofilms.
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