期刊
GENES & DEVELOPMENT
卷 26, 期 21, 页码 2386-2391出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.199588.112
关键词
Notch; reprogramming; embryo culture; commitment; plasticity
资金
- NIH National Center for Research Resources (NCRR)
- California Institute of Regenerative Medicine
- NIH [HD062922]
- March of Dimes [FY2007-804]
We report that Notch signaling is essential for the switch from developmental plasticity to commitment during Caenorhabditis elegans embryogenesis. The GLP-1 and LIN-12 Notch receptors act to set a memory state that affects commitment of cells arising from the major ectodermal progenitor (AB blastomere) several cell divisions later, thereby preventing their forced reprogramming by an endoderm-determining transcription factor. In contrast to Notch-dependent cell fate induction, this activity is autonomous to the AB lineage, is independent of the known cell fate-inducing Notch ligands, and requires a putative secreted Notch ligand, Delta Serrate Lag-3 (DSL-3). Thus, Notch signaling promotes developmental commitment by amechanism that is distinct from that involved in specifying cell fates.
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