期刊
GENES & DEVELOPMENT
卷 26, 期 4, 页码 312-324出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.184788.111
关键词
FGF15; FGF19; FGF21; bile acids; obesity; diabetes
资金
- National Institutes of Health [5R01DK067158, RL1GM084436]
- Robert A. Welch Foundation [I-1275, I-1558]
- Howard Hughes Medical Institute
We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolismin response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.
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