期刊
GENES & DEVELOPMENT
卷 26, 期 13, 页码 1427-1432出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.192872.112
关键词
body size; ecdysone; insulin signaling; maturation; mir-8; ush
资金
- National Honor Scientist Program through the National Research Foundation of Korea (NRF) [20100020415]
- BK21 Research Fellowships through the National Research Foundation of Korea (NRF)
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2012009732]
- Ministry of Education, Science, and Technology
- T.J. Park Junior Faculty Fellowship
- Chung-Ang University Research Grants
- National Research Foundation of Korea [2010-0020415, 2012R1A1A1009732, 과06A1204] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Body size determination is a process that is tightly linked with developmental maturation. Ecdysone, an insect maturation hormone, contributes to this process by antagonizing insulin signaling and thereby suppressing juvenile growth. Here, we report that the microRNA miR-8 and its target, u-shaped (USH), a conserved microRNA/target axis that regulates insulin signaling, are critical for ecdysone-induced body size determination in Drosophila. We found that the miR-8 level is reduced in response to ecdysone, while the USH level is up-regulated reciprocally, and that miR-8 is transcriptionally repressed by ecdysone's early response genes. Furthermore, modulating the miR-8 level correlatively changes the fly body size; either overexpression or deletion of miR-8 abrogates ecdysone-induced growth control. Consistently, perturbation of USH impedes ecdysone's effect on body growth. Thus, miR-8 acts as a molecular rheostat that tunes organismal growth in response to a developmental maturation signal.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据