期刊
GENES & DEVELOPMENT
卷 26, 期 22, 页码 2461-2467出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.207514.112
关键词
splicing; UV cross-linking; conformational state; pre-mRNA splicing; RNA-protein complex; RNA-protein cross-linking; spliceosome catalytic activation
资金
- National Institutes of Health [GM062264]
During pre-mRNA splicing, the spliceosome is activated for catalysis by unwinding base-paired U4/U6 small nuclear RNAs, a step that must be precisely timed. We know that unwinding requires the ATPase Brr2, but the mechanism and regulation of unwinding have been understood poorly. In the November 1, 2012, issue of Genes & Development, Hahn and colleagues (pp. 2408-2421) and Mozaffari-Jovin and colleagues (pp. 2422-2434) defined a pathway for U4/U6 unwinding. Moreover, Mozaffari-Jovin and colleagues suggested a mechanism for regulating Brr2.
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