期刊
GENES & DEVELOPMENT
卷 25, 期 4, 页码 299-309出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.2018411
关键词
embryonic development; differentiation; myocyte regeneration; stem cells
资金
- NIH [R37HL059502, R33HL088266, R01HL083463, P01HL098053]
- California Institute for Regenerative Medicine [RC1-000132]
- Mathers Charitable Foundation
- Sanford Children's Health Center, Sanford-Burnham Medical Research Institute
- British Heart Foundation
- British Heart Foundation Centre of Research Excellence
- EU
- European Research Council
- Fondation Leducq Transatlantic Network of Excellence for Cardiac Regeneration
- Medical Research Council-British Heart Foundation
- British Heart Foundation [RG/08/007/25296] Funding Source: researchfish
- Medical Research Council [G0901467] Funding Source: researchfish
- MRC [G0901467] Funding Source: UKRI
The adult human heart is an ideal target for regenerative intervention since it does not functionally restore itself after injury yet has a modest regenerative capacity that could be enhanced by innovative therapies. Adult cardiac cells with regenerative potential share gene expression signatures with early fetal progenitors that give rise to multiple cardiac cell types, suggesting that the evolutionarily conserved regulatory networks that drive embryonic heart development might also control aspects of regeneration. Here we discuss commonalities of development and regeneration, and the application of the rich developmental biology heritage to achieve therapeutic regeneration of the human heart.
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