期刊
GENES & DEVELOPMENT
卷 25, 期 8, 页码 789-794出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.2027911
关键词
Polycomb; Ezh2; satellite cells; muscle growth; muscle regeneration
资金
- NH and MRC (Australia)
- National Institute of Arthritis, Musculoskeletal, and Skin Diseases of the National Institutes of Health
Satellite cells (SCs) sustain muscle growth and empower adult skeletal muscle with vigorous regenerative abilities. Here, we report that EZH2, the enzymatic subunit of the Polycomb-repressive complex 2 (PRC2), is expressed in both Pax7(+)/Myf5(-) stem cells and Pax7(+)/Myf5(+) committed myogenic precursors and is required for homeostasis of the adult SC pool. Mice with conditional ablation of Ezh2 in SCs have fewer muscle postnatal Pax7(+) cells and reduced muscle mass and fail to appropriately regenerate. These defects are associated with impaired SC proliferation and derepression of genes expressed in nonmuscle cell lineages. Thus, EZH2 controls self-renewal and proliferation, and maintains an appropriate transcriptional program in SCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据