期刊
GENES & DEVELOPMENT
卷 25, 期 16, 页码 1674-1679出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.16860911
关键词
LRH-1; PTF1-L; exocrine pancreas; digestive enzymes; ChIP-seq; RNA-seq
资金
- Howard Hughes Medical Institute
- National Institutes of Health [F32-DK079544, U19-DK06243409, R01-DK061220]
- Robert A. Welch Foundation [I-1275, I-1558]
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mitochondrial proteins. LRH-1 cooperates with the pancreas transcription factor 1-L complex (PTF1-L) in regulating exocrine pancreas-specific gene expression. Elimination of LRH-1 in adult mice reduced the concentration of several lipases and proteases in pancreatic fluid and impaired pancreatic fluid secretion in response to cholecystokinin. Thus, LRH-1 is a key regulator of the exocrine pancreas-specific transcriptional network required for the production and secretion of pancreatic fluid.
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