4.7 Article

Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18

期刊

GENES & DEVELOPMENT
卷 25, 期 12, 页码 1289-1305

出版社

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.624711

关键词

MRP-L18; mitochondria; human; ribosome; RNA import; chaperone

资金

  1. CNRS
  2. Universite de Strasbourg
  3. Moscow State University
  4. AFM (Association Francaise contre les Myopathies)
  5. ANR (Agence Nationale de la Recherche)
  6. FRM (Fondation pour la Recherche Medicale)
  7. ARCUS (cooperation program Alsace-Russia-Ukraine)

向作者/读者索取更多资源

5S rRNA is an essential component of ribosomes of all living organisms, the only known exceptions being mitochondrial ribosomes of fungi, animals, and some protists. An intriguing situation distinguishes mammalian cells: Although the mitochondrial genome contains no 5S rRNA genes, abundant import of the nuclear DNA-encoded 5S rRNA into mitochondria was reported. Neither the detailed mechanism of this pathway nor its rationale was clarified to date. In this study, we describe an elegant molecular conveyor composed of a previously identified human 5S rRNA import factor, rhodanese, and mitochondrial ribosomal protein L18, thanks to which 5S rRNA molecules can be specifically withdrawn from the cytosolic pool and redirected to mitochondria, bypassing the classic nucleolar reimport pathway. Inside mitochondria, the cytosolic 5S rRNA is shown to be associated with mitochondrial ribosomes.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据