4.7 Article

A new 'Linc' between noncoding RNAs and blood development

期刊

GENES & DEVELOPMENT
卷 25, 期 24, 页码 2555-2558

出版社

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.183020.111

关键词

long noncoding RNA; erythroid terminal differentiation; apoptosis

资金

  1. Roche Foundation for Anemia Research (RoFAR)

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Long noncoding RNAs (lncRNAs) are a large and diverse class of functional RNAs that regulate important biological processes, including cell division, survival, and differentiation. In this issue of Genes & Development, Hu and colleagues (2573-2578) report the discovery of LincRNA erythroid prosurvival (LincRNA-EPS), a murine lncRNA that facilitates red blood cell formation (erythropoiesis) by suppressing apoptosis. This finding expands the repertoire of lncRNA functions and illustrates a novel genetic pathway that potentially can be exploited for treating anemias.

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