期刊
GENES & DEVELOPMENT
卷 24, 期 22, 页码 2463-2479出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1971610
关键词
Telomeres; oncogenes; tumor suppressor genes; senescence; in vivo; biomarkers
资金
- Dutch Cancer Society
- Netherlands Organization for Scientific Research (NWO)
Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of cellular senescence in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.
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