期刊
GENES & DEVELOPMENT
卷 24, 期 9, 页码 862-874出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1909210
关键词
Hippo; YAP; phosphorylation; cancer; organ size
资金
- NIH [CA132809, GM62694]
- National High Technology Research and Development Program of China [2006AA02A308]
- State Key Development Program for Basic Research of China [2009CB918401]
- National Natural Science Foundation of China [30600112, 30871255]
- Shanghai key project [08JC1400800, 09JC1402300]
- Shanghai Leading Academic Discipline Project [B110]
- NATIONAL CANCER INSTITUTE [R01CA132809] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062694] Funding Source: NIH RePORTER
The Hippo signaling pathway is gaining recognition as an important player in both organ size control and tumorigenesis, which are physiological and pathological processes that share common cellular signaling mechanisms. Upon activation by stimuli such as high cell density in cell culture, the Hippo pathway kinase cascade phosphorylates and inhibits the Yes-associated protein (YAP)/TAZ transcription coactivators representing the major signaling output of the pathway. Altered gene expression resulting from YAP/TAZ inhibition affects cell number by repressing cell proliferation and promoting apoptosis, thereby limiting organ size. Recent studies have provided new insights into the Hippo signaling pathway, elucidating novel phosphorylation-dependent and independent mechanisms of YAP/Yki inhibition by the Hippo pathway, new Hippo pathway components, novel YAP target transcription factors and target genes, and the three-dimensional structure of the YAP-TEAD complex, and providing further evidence for the involvement of YAP and the Hippo pathway in tumorigenesis.
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