期刊
GENES & DEVELOPMENT
卷 24, 期 20, 页码 2264-2269出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.590910
关键词
RNA polymerase I; noncoding RNA; DNA methylation; DNA:RNA triplexes; DNMTs
资金
- European Research Council
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie
Noncoding RNAs are important components of regulatory networks controlling the epigenetic state of chromatin. We analyzed the role of pRNA (promoter-associated RNA), a noncoding RNA that is complementary to the rDNA promoter, in mediating de novo CpG methylation of rRNA genes (rDNA). We show that pRNA interacts with the target site of the transcription factor TTF-I, forming a DNA: RNA triplex that is specifically recognized by the DNA methyltransferase DNMT3b. The results reveal a compelling new mechanism of RNA-dependent DNA methylation, suggesting that recruitment of DNMT3b by DNA: RNA triplexes may be a common and generally used pathway in epigenetic regulation.
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