期刊
GENES & DEVELOPMENT
卷 24, 期 12, 页码 1201-1207出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1944710
关键词
Meiosis; recombination; double-strand break
资金
- Ruth L. Kirschstein National Research Service [F32HD51392]
- National Institutes of Health [R01HD40916, R01HD53855]
Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.
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