期刊
GENES & DEVELOPMENT
卷 24, 期 22, 页码 2493-2498出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1989510
关键词
Piwi; Armitage; Yb; Zucchini; primary piRNA; Drosophila
资金
- MEXT (Ministry of Education, Culture, Sports, Science, and Technology of Japan)
- JSPS (Japan Society for the Promotion of Science)
- CREST from the JST
PIWI-interacting RNAs (piRNAs) protect genome integrity from transposons. In Drosophila ovarian somas, primary piRNAs are produced and loaded onto Piwi. Here, we describe roles for the cytoplasmic Yb body components Armitage and Yb in somatic primary piRNA biogenesis. Armitage binds to Piwi and is required for localizing Piwi into Yb bodies. Without Armitage or Yb, Piwi is freed from the piRNAs and does not enter the nucleus. Thus, piRNA loading is required for Piwi nuclear entry. We propose that a functional Piwi-piRNA complex is formed and inspected in Yb bodies before its nuclear entry to exert transposon silencing.
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