期刊
GENES & DEVELOPMENT
卷 23, 期 5, 页码 537-548出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1756509
关键词
Cancer biology; cellular metabolism; tumor suppressors; oncogenes; proliferation; apoptosis
资金
- Canadian Institutes of Health Research
- National Institutes of Health [RO1 CA105463-01]
- McGill University Faculty of Medicine
- NATIONAL CANCER INSTITUTE [R01CA105463] Funding Source: NIH RePORTER
Growing tumors face two major metabolic challenges-how to meet the bioenergetic and biosynthetic demands of increased cell proliferation, and how to survive environmental fluctuations in external nutrient and oxygen availability when tumor growth outpaces the delivery capabilities of the existing vasculature. Cancer cells display dramatically altered metabolic circuitry that appears to directly result from the oncogenic mutations selected during the tumorigenic process. An emerging theme in cancer biology is that many of the genes that can initiate tumorigenesis are intricately linked to metabolic regulation. In turn, it appears that a number of well-established tumor suppressors play critical roles in suppressing growth and/or proliferation when intracellular supplies of essential metabolites become reduced. In this review, we consider the potential role of tumor suppressors as metabolic regulators.
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