期刊
GENES & DEVELOPMENT
卷 23, 期 22, 页码 2598-2603出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.552109
关键词
Transvection; imprinting; epigenetics; replication timing; H19 ICR
资金
- Swedish Science Research Council
- Swedish Cancer Research Foundation
- Swedish Pediatric Cancer Foundation
- Lundberg Foundation
- HEROIC
- ChILL (EU integrated projects)
Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据