期刊
GENES & DEVELOPMENT
卷 23, 期 23, 页码 2675-2699出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1850809
关键词
Asymmetric cell division; cell polarity; neurogenesis; stem cell; tumorigenesis
资金
- Austrian Academy of Sciences
- Austrian Science Fund (FWF)
- EU network ONCASYM
- EU Framework 7
Cell division is commonly thought to involve the equal distribution of cellular components into the two daughter cells. During many cell divisions, however, proteins, membrane compartments, organelles, or even DNA are asymmetrically distributed between the two daughter cells. Here, we review the various types of asymmetries that have been described in yeast and in animal cells. Asymmetric segregation of protein determinants is particularly relevant for stem cell biology. We summarize the relevance of asymmetric cell divisions in various stem cell systems and discuss why defects in asymmetric cell division can lead to the formation of tumors.
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