期刊
GENES & DEVELOPMENT
卷 23, 期 7, 页码 784-787出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1795309
关键词
Senescence; autophagy; oncogene
资金
- NCI NIH HHS [R01 CA130893, P30 CA008748, P01 CA087497] Funding Source: Medline
Autophagy and senescence are two distinct cellular responses to stress that are also tumor suppression mechanisms. In this issue of Genes & Development, Young and colleagues ( pp. 798-803) discovered that autophagy is induced during and facilitates the process of senescence. Knowing now that these two pathways are functionally intertwined sets the stage for establishing how they function cooperatively in the cancer setting.
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