期刊
GENES & DEVELOPMENT
卷 23, 期 24, 页码 2812-2817出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1839209
关键词
Sirt1; growth hormone; calorie restriction; aging
资金
- CHDI, Inc.
- Hereditary Disease Foundation
- American Parkinson's Disease Association
- NIH
- Paul F. Glenn Foundation
Mammalian life span can be extended by both calorie restriction (CR) and mutations that diminish somatotropic signaling. Sirt1 is a mediator of many effects of CR in mammals, but any role in controlling somatotropic signaling has not been shown. Since the somatotropic axis is controlled by the brain, we created mice lacking Sirt1 specifically in the brain and examined the impacts of this manipulation on somatotropic signaling and the CR response. These mutant mice displayed defects in somatotropic signaling when fed ad libitum, and defects in the endocrine and behavioral responses to CR. We conclude that Sirt1 in the brain is a link between somatotropic signaling and CR in mammals.
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