期刊
GENES & DEVELOPMENT
卷 23, 期 16, 页码 1870-1875出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1823109
关键词
ES cell heterogeneity; Hes1 oscillation; Notch signaling; Dll1; Gadd45g
资金
- Genome Network Project
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Mitsubishi Foundation
- Uehara Memorial Foundation
- Japan Society for the Promotion of Science for Young Scientists
- Grants-in-Aid for Scientific Research [21240028] Funding Source: KAKEN
Stem cells do not all respond the same way, but the mechanisms underlying this heterogeneity are not well understood. Here, we found that expression of Hes1 and its downstream genes oscillate in mouse embryonic stem (ES) cells. Those expressing low and high levels of Hes1 tended to differentiate into neural and mesodermal cells, respectively. Furthermore, inactivation of Hes1 facilitated neural differentiation more uniformly at earlier time. Thus, Hes1-null ES cells display less heterogeneity in both the differentiation timing and fate choice, suggesting that the cyclic gene Hes1 contributes to heterogeneous responses of ES cells even under the same environmental conditions.
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