期刊
GENES & DEVELOPMENT
卷 23, 期 9, 页码 1027-1031出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1805309
关键词
Chromatin; DNA double-strand break; DNA repair; Mps3p; Rad52; 3C
资金
- NIH
- March of Dimes
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM051402] Funding Source: NIH RePORTER
Persistent DNA double-strand breaks and telomeres represent genomic hazards, as they can instigate inappropriate repair reactions. Two recent papers by Oza and colleagues (pp. 912-917) and Schober and colleagues (pp. 928-938) show that both types of DNA ends are sequestered from bulk DNA by Mps3, a SUN domain protein that spans the inner nuclear membrane. Anchorage maintains telomere integrity and steers double-strand breaks toward specialized repair pathways. This work defines the nuclear periphery as a subcompartment where dangerous DNA elements can be handled with care.
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