期刊
GENES & DEVELOPMENT
卷 22, 期 12, 页码 1567-1571出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1690508
关键词
genomic imprinting; DNA methylation; pre-implantation embryos; Dnmt1
资金
- MRC [G0700098] Funding Source: UKRI
- Medical Research Council [G0700098] Funding Source: researchfish
- Medical Research Council [G0700098] Funding Source: Medline
During early mammalian embryogenesis, the genome undergoes global epigenetic reprogramming, losing most of its methylation before re-establishing it de novo at implantation. However, faithful maintenance of methylation at imprinted genes during this process is vital for embryonic development, but the DNA methyltransferase responsible for this maintenance has remained unknown. In this issue of Genes & Development, Hirasawa and colleagues (pp. 1607-1616) show that Dnmt1, and not Dnmt3a or Dnmt3b, maintains methylation at genomic imprints during preimplantation development.
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