期刊
GENES & DEVELOPMENT
卷 22, 期 11, 页码 1534-1548出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1638308
关键词
APC/C; CDK; Cdc20; spindle elongation; mitosis
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R29 GM056800, R01 GM056800, GM 56800] Funding Source: Medline
Mitotic cyclin-dependent kinases (CDKs) control entry into mitosis, but their role during mitotic progression is less well understood. Here we characterize the functions of CDK activity associated with the mitotic cyclins Clb1, Clb2, and Clb3. We show that Clb-CDKs are important for the activation of the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C)-Cdc20 that triggers the metaphase-anaphase transition. Furthermore, we define an essential role for Clb-CDK activity in anaphase spindle elongation. Thus, mitotic CDKs serve not only to initiate M phase, but are also needed continuously throughout mitosis to trigger key mitotic events such as APC/C activation and anaphase spindle elongation.
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