Treatment of delirium with ramelteon: initial experience in three patients

Objective: The aim of the present study was to determine the efficacy of ramelteon for treating delirium. Methods: Three patients were prescribed ramelteon for delirium. The severity of the delirium was assessed using the Japanese version of the Memorial Delirium Assessment Scale. Results: Memorial Delirium Assessment Scale scores improved after treatment with ramelteon in all cases. Conclusion: These cases suggest that ramelteon may be beneficial in the treatment of delirium. Randomized controlled studies are needed to confirm the therapeutic benefits. (C) 2011 Elsevier Inc. All rights reserved.