期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 268, 期 -, 页码 34-39出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2018.07.013
关键词
Insulin-like receptors; Phylogeny; Gene duplication; Crustaceans; Sexual differentiation
资金
- Centre National de la Recherche Scientifique (CNRS)
- French Ministry of Higher Education and Research
The Insulin-like Receptors (IRs) are an important protein family, represented by three members in vertebrates, two of which are well-known for their implication in metabolism (Insulin Receptor) and growth (IGF Receptor). In contrast, little is known about these receptors in invertebrates, in which a single gene generally exists except for a part of insects and other occasional species-specific duplications. In this study, we used publicly available sequences as well as de novo assembled transcriptomes to investigate the IR evolution in malacostracan crustaceans, animals in which the Insulin/IGF pathway is known to be implicated in sexual development through the androgenic gland hormone. We described the evolutionary divergence of malacostracan IRs compared to all the other metazoan sequences, including other pancrustaceans. We also demonstrated two well conserved duplications of IRs: one specific to the whole malacostracan class, another one specific to the decapod order. The potential implications for malacostracan biology are discussed.
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