期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 273, 期 -, 页码 227-235出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2018.09.005
关键词
Bacterial killing ability; PHA; Hormone; Immune response; Anura; Caatinga
资金
- State of Sao Paulo Science Foundation (FAPESP) [2013/00900-1, 2012/24206-4]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/00900-1] Funding Source: FAPESP
Androgens and glucocorticoids play important roles in vertebrate's reproduction and display complex immunomodulatory functions that may affect survival. In anurans, testosterone and corticosterone are correlated to sexual behavior, reproduction, and immune function. Male toads (Rhinella jimi) were treated with acute doses of testosterone (T) and corticosterone (CORT) and immune variables (plasma bacterial killing ability [BKA], swelling after phytohemagglutinin [PHA] injection and the time point of maximum PHA swelling response) were measured. Transdermal T and CORT application increased androgen (T-DHT) and CORT plasma levels after 1 h of treatment, respectively, without a dose-specific effect. Transdermal T treatment did not affect BKA or PHA swelling response. Individuals treated with transdermal CORT showed an earlier maximum PHA swelling response and a tendency of lower BKA 15 h after treatment. Our results indicated that an acute experimental increase of CORT plasma levels diminished time for inflammatory resolution and suppressed non-cellular innate response.
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