期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 203, 期 -, 页码 132-136出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2014.01.011
关键词
Inflammation; Stress; Reproduction; Spondyloarthritis; Osteoarthritis; Rheumatoid arthritis
资金
- Council of Science and Technology of Mexico (CONACYT) [161594]
- Ph.D. Program in Biomedical Sciences of the National University of Mexico (UNAM) [IN200312]
Arthritic disorders are family of diseases that have existed since vertebrate life began. Their etiology is multifactorial with genetic, environmental, and gender factors driving chronic joint inflammation. Prolactin is a sexually dimorphic hormone in mammals that can act to both promote and ameliorate rheumatic diseases. It is found in all vertebrate groups where it exerts a wide diversity of actions. This review briefly addresses the presence and features of arthritic diseases in vertebrates, the effects of PRL on joint tissues and immune cells, and whether PRL actions could have contributed to the ubiquity of arthritis in nature. This comparative approach highlights the value of PRL as a biologically conserved factor influencing the development and progression of arthritis. (C) 2014 Elsevier Inc. All rights reserved.
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