期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 195, 期 -, 页码 157-163出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2013.10.015
关键词
G-protein coupled receptor; Steroid hormone; Catecholamine; Rapid, non-genomic actions
资金
- BBSRC through the Babraham Institute
- BBSRC Studentship
- Biotechnology and Biological Sciences Research Council [BB/E00153X/1] Funding Source: researchfish
- BBSRC [BB/E00153X/1] Funding Source: UKRI
Steroid hormones classically mediate their actions by binding to intracellular receptor proteins that migrate to the nucleus and act as transcription factors to change gene expression. However, evidence is now accumulating for rapid, non-genomic effects of steroids. There is considerable controversy over the mechanisms underlying such effects. In a number of cases evidence has been presented for the direct activation of G-protein coupled receptors (GPCRs) by steroids, either at the plasma membrane, or at intracellular locations. Here, we will focus on the non-genomic actions of ecdysteroids on a Drosophila GPCR, DopEcR (CG18314), which can be activated by both ecdysone and the catecholamine, dopamine. We will also point out parallels between this system and the activation of the vertebrate GPCR, GPER1 (GPR30), which is thought to be activated by 17 beta-estradiol. We propose that the cellular localization and signalling properties of both DopEcR and GPER1 may be cell specific and depend upon their interactions with both accessory molecules and signalling pathways. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.
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