期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 193, 期 -, 页码 149-157出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2013.07.019
关键词
Glucocorticoids; Stress; Innate immune function; Bacteria killing ability; Ground squirrels
资金
- National Science Foundation [IOB 05-17137]
- University of Chicago Hind's Fund
- Valentine Eastern Sierra Reserve Graduate Student Grant
- American Society of Mammalogists
- Sigma Xi
- American Museum of Natural History Theodore Roosevelt Memorial Grant
The hypothalamic-pituitary-adrenal (HPA) axis releases glucocorticoids (GCs), or stress hormones, during the vertebrate stress response. GCs can both enhance and suppress the immune system depending on whether the experienced stressor is acute or chronic and what aspect of immune function is measured. More research is needed to fully understand how the immune system reacts to stressors. In this study, we examined the effects of chronically raised GCs on innate immune function in Belding's ground squirrels (Urocitellus beldingi). We measured immune function with a bacteria killing ability (BKA) assay, an integrative and functional assessment of an animal's ability to clear a bacterial infection. All studies to date have examined how acute stressors or repeated social stressors impact BMA. This study is the first to our knowledge to investigate how chronically raised GCs impact BM both before and after an immune challenge. We noninvasively raised GCs in treatment squirrels for six days and then gave them, and a group of untreated (control) squirrels, an injection of lipopolysaccharide (LPS) to stimulate their innate immune system. Treatment squirrels exhibited lower BM after, but not before, being challenged with LPS. These results suggest that experiencing chronic stress may not be detrimental to immune functioning until an individual is challenged with an infection. (C) 2013 Elsevier Inc. All rights reserved.
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