期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 162, 期 1, 页码 113-121出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2008.09.012
关键词
Innate immunity; Drosophila; Secretary epithelia; Malpighian tubules autocrine; Nitric oxide
资金
- United Kingdom Biotechnological and Biological Sciences Research Council, BBSRC
- Biotechnology and Biological Sciences Research Council [BB/G020620/1, BB/E011438/1] Funding Source: researchfish
- BBSRC [BB/E011438/1, BB/G020620/1] Funding Source: UKRI
Mechanisms of innate immunity especially with relevance to epithelial tissue, are currently the focus of intense research, as epithelial immunity greatly impacts on health and disease. However, many findings regarding innate immunity signalling pathways in vertebrates stems from research using the genetic model Drosophila melanogaster. Here we discuss the central importance of epithelial tissues in innate immunity in Drosophila: the modulation of the Imd pathway via autocrine production of nitric oxide (NO); and the central importance of the Malpighian (renal) tubule in immune function of the whole animal. (C) 2008 Elsevier Inc. All rights reserved.
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