期刊
GENE THERAPY
卷 18, 期 12, 页码 1104-1110出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2011.50
关键词
miRNA; antagomir; anti-miR; Argonaute; RNA silencing; miRNA inhibition
类别
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R37 GM062862, R01 GM065236-10, R01 GM065236, R37 GM062862-12] Funding Source: Medline
MicroRNAs (miRNAs) provide new therapeutic targets for many diseases, while their myriad roles in development and cellular processes make them fascinating to study. We still do not fully understand the molecular mechanisms by which miRNAs regulate gene expression nor do we know the complete repertoire of mRNAs each miRNA regulates. However, recent progress in the development of effective strategies to block miRNAs suggests that anti-miRNA drugs may soon be used in the clinic. Gene Therapy (2011) 18, 1104-1110; doi:10.1038/gt.2011.50; published online 28 April 2011
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