期刊
GENE THERAPY
卷 17, 期 6, 页码 811-814出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2010.22
关键词
cellular immune response; DNA-coated microneedle; DNA vaccine; hepatitis C virus; microfabricated needle
类别
资金
- Swedish Science Council
- Cancer Foundation
- Stockholm County Council
- US National Institutes of Health
- Robert M Nerem Travel Award
The skin is potentially an excellent organ for vaccine delivery because of accessibility and the presence of immune cells. However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery. Vaccination with a plasmid encoding hepatitis C virus nonstructural 3/4A protein using microneedles effectively primed specific cytotoxic T lymphocytes (CTLs). Importantly, the minimally invasive microneedles were as efficient in priming CTLs as more complicated or invasive delivery techniques, such as gene gun and hypodermic needles. Thus, microneedles may offer a promising technology for DNA vaccination. Gene Therapy (2010) 17, 811-814; doi: 10.1038/gt.2010.22; published online 4 March 2010
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