期刊
GENE EXPRESSION PATTERNS
卷 13, 期 7, 页码 212-224出版社
ELSEVIER
DOI: 10.1016/j.gep.2013.02.007
关键词
LysM domains; TLDc domains; OXR; CNS; Zebrafish
资金
- CARB centre
- Danish National Research Foundation
- Aarhus University (AU)
- Leiden University Biology Institute (IBL)
- [DNRF79]
The function and structure of LysM-domain containing proteins are very diverse. Although some LysM domains are able to bind peptidoglycan or chitin type carbohydrates in bacteria, in fungi and in plants, the function(s) of vertebrate LysM domains and proteins remains largely unknown. In this study we have identified and annotated the six zebrafish genes of this family, which encode at least ten conceptual LysM-domain containing proteins. Two distinct sub-families called LysMD and OXR were identified and shown to be highly conserved across vertebrates. The detailed characterization of LysMD and OXR gene expression in zebrafish embryos showed that all the members of these sub-families are strongly expressed maternally and zygotically from the earliest stages of a vertebrate embryonic development. Moreover, the analysis of the spatio-temporal expression patterns, by whole mount and fluorescent in situ hybridizations, demonstrates pronounced LysMD and OXR gene expression in the zebrafish brain and nervous system during stages of larval development. None of the zebrafish LysMD or OXR genes was responsive to challenge with bacterial pathogens in embryo models of Salmonella and Mycobacterium infections. In addition, the expression patterns of the OXR genes were mapped in a zebrafish brain atlas. (c) 2013 Elsevier B.V. All rights reserved.
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