期刊
GENE EXPRESSION PATTERNS
卷 8, 期 7-8, 页码 477-480出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gep.2008.07.001
关键词
Hypoblast; Endoblast; Endoderm; Primitive streak; Chicken; Gastrulation; Apolipoprotein; Anterior intestinal portal; Liver; ITGBIBP3; MKRN1; LDHB; TPM1; ACSL3; Integrin beta-1 binding protein 3; Makorin 1; Lactate dehydrogenase B; alpha-Tropomyosin; Acyl-CoA1 synthetase long-chain 3
资金
- BBSRC
- Medical Research Council
- EU FP6 Network of Excellence Cells into Organs
- MRC [G0400559] Funding Source: UKRI
- Medical Research Council [G0400559] Funding Source: researchfish
The lower layer of the pre-gastrulating chick embryo is an extra-embryonic tissue made up of two different cell Populations, the hypoblast and the endoblast. The hypoblast is characterized by the expression of inhibitory signalling molecules (e.g. Cerberus, Dickkopf1, Crescent) and others (e.g. Otx2, goosecoid, Hex, Hesx1/RPX, FGF8). However, no genes expressed in the endoblast have yet been found. We designed a differential screen to identify markers differentially expressed in these two cell populations. This only revealed one novel gene, Apolipoprotein A1 (APO A1) with restricted endodermal layer expression. Expression of APO A I begins very early throughout the lower layer (both hypoblast and endoblast). At later stages it is also expressed in the endoderm and its derivatives, the anterior intestinal portal endoderm and the growing liver bud. (C) 2008 Elsevier B.V. All rights reserved.
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