4.6 Article

Intertypic modular exchanges of genomic segments by homologous recombination at universally conserved segments in human adenovirus species D

期刊

GENE
卷 547, 期 1, 页码 10-17

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2014.04.018

关键词

Recombination hotspot; Homologous recombination; Synonymous substitution rate; Modular exchange; Adenovirus

资金

  1. MEXT KAKENHI [22125009]
  2. Japan Initiative for Global Research Network of Infectious Diseases (J-GRID), MEXT, Japan
  3. Grants-in-Aid for Scientific Research [25462731, 22125009] Funding Source: KAKEN

向作者/读者索取更多资源

Human adenovirus species D (HAdV-D), which is composed of clinically and epidemiologically important pathogens worldwide, contains more taxonomic types than any other species of the genus Mastadenovirus, although the mechanisms accounting for the high level of diversity remain to be disclosed. Recent studies of known and new types of HAdV-D have indicated that intertypic recombination between distant types contributes to the increasing diversity of the species. However, such findings raise the question as to how homologous recombination events occur between diversified types since homologous recombination is suppressed as nucleotide sequences diverge. In order to address this question, we investigated the distribution of the recombination boundaries in comparison with the landscape of intergenomic sequence conservation assessed according to the synonymous substitution rate (d(s)). The results revealed that specific genomic segments are conserved between even the most distantly related genomes; we call these segments universally conserved segments (UCSs). These findings suggest that UCSs facilitate homologous recombination, resulting in intergenomic segmental exchanges of UCS-flanking genomic regions as recombination modules. With the aid of such a mechanism, the haploid genomes of HAdV-Ds may have been reshuffled, resulting in chimeric genomes out of diversified repertoires in the HAdV-D population analogous to the MHC region reshuffled via crossing over in vertebrates. In addition, some HAdVs with chimeric genomes may have had the opportunity to avoid host immune responses thereby causing epidemics. (C) 2014 Elsevier B.V. All rights reserved.

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