期刊
GENE
卷 544, 期 1, 页码 1-7出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2014.04.039
关键词
MicroRNA (miRNA); IsomiR; Expression pattern; Evolutionary pattern
资金
- National Natural Science Foundation of China [61301251, 81072389]
- Research Fund for the Doctoral Program of Higher Education of China [211323411002, 20133234120009]
- China Postdoctoral Science Foundation [2012M521100]
- Key Grant of the Natural Science Foundation of the Jiangsu Higher Education Institutions of China [10KJA33034]
- National Natural Science Foundation of Jiangsu [BK20130885]
- Natural Science Foundation of the Jiangsu Higher Education Institutions [13KJB330003]
- Jiangsu Planned Projects for Postdoctoral Research Funds [1201022B]
- Science and Technology Development Fund Key Project of Nanjing Medical University [2012NJMU001]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Accumulating evidence suggests that a single microRNA (miRNA) locus can generate a series of sequences during miRNA maturation process. These multiple sequences, called miRNA variants, or isomiRs, have different lengths and different 5' and 3' ends. Some of these isomiRs are detected as varied nucleotides and 3' additional non-template nucleotides. As physiological miRNA isoforms, they have drawn attention for possible regulatory biological roles. The present work mainly reviews miRNA/isomiR biogenesis, isomiR expression patterns, and functional and evolutionary implications, especially between isomiRs from homologous and clustered miRNA loci. The phenomenon of multiple isomiRs and their biological roles indicates that analysis performed at the miRNA and isomiR levels should be included in miRNA studies. This may enrich and complicate miRNA biogenesis and coding-non-coding RNA regulatory networks. (C) 2014 Elsevier B.V. All rights reserved.
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