期刊
GENE
卷 535, 期 2, 页码 218-224出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2013.11.031
关键词
Breast cancer; Mdig; Prognosis; Patient survival
资金
- NIH [R01 ES017217, R01 ES020137]
Breast cancer is the most common cancer and the second leading cause of cancer death among women of all races and Hispanic origin populations in the United States. In the present study, we reported that the survival time of the breast cancer patients is influenced by the expression level of mdig, a previously identified lung cancer-associated oncogene encoding a JmjC-domain protein. By checking the expression levels of mRNA and protein of mdig through both RT-PCR and immunohistochemistry in samples from 204 patients, we noticed that about 30% of breast cancer samples showed increased expression of mdig. Correlation of the mdig expression levels with the survival time of the breast cancer patients indicated a, clear inverse relationship between mdig expression and patient survival, including poorer overall survival, distant metastasis free survival, relapse free survival, and post-progression survival. Taken together, these data suggest that an increased expression of mdig is an important prognostic factor for poorer survival time of the breast cancer patients. (C) 2013 Elsevier B.V. All rights reserved.
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