期刊
GENE
卷 524, 期 2, 页码 373-376出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2013.04.032
关键词
DJ-1; C. elegans; Glyoxalase; Dauer; DAF-16
资金
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries [110056-03-3-HD120]
Caenorhabditis elegans DJR-1.2, a homolog of human DJ-1, has recently been demonstrated to be a novel glyoxalase and protects worms against glyoxals. Here, we report that expression of DJR-1.2 is substantially increased during starvation as well as in the dauer stage. The induction of DJR-1.2 led to increased glyoxalase activity in the dauer state, thereby increasing protection against glyoxals. The induction is regulated by DAF-16, a transcriptional regulator implicated in oxidative stress and normal lifespan. (C) 2013 Elsevier B.V. All rights reserved.
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