Effects of polymorphisms in nucleotide excision repair genes on glioma risk in a Chinese population

We performed a case-control study to assess the relationship between six single nucleotide polymorphisms (SNPs) of xeroderma pigmentosum complementation group F (XPF) on glioma risk in a Chinese population. The six SNPs were genotyped in 330 glioma cases and 652 cancer-free controls using a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). Rs1800067 did not follow the Hardy-Weinberg equilibrium in the control group, and the genotype distributions differed significantly between the two groups for SNPs rs1800067 and rs2276466. For rs1800067, the variant genotype T/T was strongly associated with an increased risk of glioma when compared with the A/A genotype (OR = 3.77,95% Cl =. 238-6.01). Individuals with the rs1800067 G allele had a relatively high risk of glioma in a dominant model (OR = 3.47, 95% CI = 2.26-5.37). The rs2276466 GIG genotype was significantly associated with a moderate increased risk of glioma (OR = 1.82,95% Cl = 1.10-3.02) in a codominant model, and variation of rs25489 was associated with a 131- and 1.78-fold glioma risk in dominant and recessive models, respectively. Our study is the first to identify polymorphisms in rs1800067 and rs2276466 as correlated with glioma susceptibility. (C) 2013 Elsevier B.V. All rights reserved.