期刊
GENE
卷 499, 期 1, 页码 130-134出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2011.11.057
关键词
Biomineralization; Calcite; Pacific oyster; Poly-alanine; Spider-silk protein
资金
- Japan Society for the Promotion of Science (JSPS) [18380124]
- Sekisui Chemical Grant Program for Research on Manufacturing Based on Learning from Nature
- Grants-in-Aid for Scientific Research [22687016, 18380124, 10J00742] Funding Source: KAKEN
During shell formation, little is known about the functions of organic matrices, especially about the biomineralization of shell prismatic layer. We identified a novel gene, shelk2, from the Pacific oyster presumed to be involved in the shell biosynthesis. The Pacific oyster has multiple copies of shelk2. Shelk2 mRNA is specifically expressed on the mantle edge and is induced during shell regeneration, thereby suggesting that Shelk2 is involved in shell biosynthesis. To our surprise, the database search revealed that it encodes a spider silk-like alanine-rich protein. Interestingly, most of the Shelk2 primary structure is composed of two kinds of poly-alanine motifs-GXNA(n)(S) and GSA(n)(S)-where X denotes Gln, Arg or no amino acid. Occurrence of common motifs of Shelk2 and spider silk led us to the assumption that shell and silk are constructed under similar strategies despite of their living environments. (C) 2011 Elsevier B.V. All rights reserved.
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