期刊
GENE
卷 503, 期 2, 页码 244-247出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2012.04.078
关键词
Insulin-like growth factor; Gene polymorphism; Breast cancer; Prognosis
We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p = 0.04), with low histological grade (p = 0.04), with positive hormone receptor status (p = 0.01), and in patients without recurrence (p = 0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. (C) 2012 Elsevier B.V. All rights reserved.
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