期刊
GENE
卷 442, 期 1-2, 页码 55-62出版社
ELSEVIER
DOI: 10.1016/j.gene.2009.04.003
关键词
Neurogranin; Brain; Murine leukemia virus; Insertional mutagenesis; T-cell lymphoma
资金
- Danish Agency for Science, Technology and Innovation
- Danish Cancer Society
- Novo Nordic Foundation
- Danish Cancer Foundation
- Karen Elise Jensen Foundation
- NIH [R01A141570]
Neurogranin (Nrgn) is a highly expressed brain-specific protein, which sequesters calmodulin at low Ca2+ levels. We report here on retroviral activation of the Nrgn gene in tumors induced by the T-cell lymphomagenic SL3-3 murine leukemia virus. We have performed a systematic expression analysis of Nrgn in various mouse tissues and SL3-3 induced T-cell tumors. This demonstrated that insertional activation of Nrgn increased RNA and protein expression levels to that observed in brain. Furthermore, elevated Nrgn expression was also observed in some T-cell tumors with no detected provirus integrations into this genomic region. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice. (C) 2009 Elsevier B.V. All rights reserved.
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