期刊
GENE
卷 427, 期 1-2, 页码 99-103出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2008.08.025
关键词
Two component regulatory system; RNA transcription; Transcriptional terminators
资金
- National Science Council [NSC94-2320-B-006-085, NSC95-2320-B-006-024]
- National Health Research Institutes, Taiwan [NHRI-EX95-9429SP]
CovR/S is an important two component regulatory system, which regulates about 15% of the gene expression in Streptococcus pyogenes. The covR/S locus was identified as an operon generating an RNA transcript around 2.5-kb in size. In this study, we found the covR/S operon produced three RNA transcripts (around 2.5-,1.0-, and 0.8-kb in size). Using RNA transcriptional terminator sequence prediction and transcriptional terminator analysis, we identified two atypical rho-independent terminator sequences downstream of the covR gene and showed these terminator sequences terminate RNA transcription efficiently. These results indicate that covR/S operon generates covR/S transcript and monocistronic covR transcripts. (C) 2008 Elsevier B.V. All rights reserved.
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