期刊
GEBURTSHILFE UND FRAUENHEILKUNDE
卷 70, 期 8, 页码 625-633出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250182
关键词
molecular heterogeneity; targeted therapies; triple negative; molecular subclass; small molecules
Breast cancer is characterized by a fundamental heterogeneity, the extent of which has been demonstrated in numerous scientific studies. Currently, breast cancer is divided into three major subgroups: luminal, Her-2 positive, and triple negative breast cancer. Despite considerable advances in the therapy of patients with breast cancer, further optimization of current therapeutic strategies is necessary and possible. While the therapy of luminal and Her-2 positive breast cancers focuses on preventing and overcoming tumoral resistance, research into triple negative breast cancer concentrates on developing and establishing novel targeted therapeutic agents.
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