期刊
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
卷 42, 期 1, 页码 133-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2012.11.008
关键词
Eosinophilic esophagitis; Diagnosis; Treatment; Epidemiology; Endoscopy; Allergy
资金
- NIH [1K23 DK090073-01]
- AstraZeneca
- Meritage Pharma
- Olympus
- ACG
- AGA
- CURED Foundation
Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition whereby infiltration of eosinophils into the esophageal mucosa leads to symptoms of esophageal dysfunction. EoE is encountered in a substantial proportion of patients undergoing diagnostic upper endoscopy. This review discusses the clinical, endoscopic, and histologic features of EoE and presents the most recent guidelines for its diagnosis. Selected diagnostic dilemmas are described, including distinguishing EoE from gastroesophageal reflux disease and addressing the newly recognized clinical entity of proton-pump inhibitor-responsive esophageal eosinophilia. Also highlighted is evidence to support both pharmacologic and nonpharmacologic treatments, including topical corticosteroids, dietary elimination therapy, and endoscopic dilation.
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