期刊
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
卷 42, 期 2, 页码 285-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2013.01.006
关键词
Helicobacter pylori; Gastric cancer; Virulence factors
资金
- NIH [P01 CA116087, R01 CA77955, R01 DK58587, DK-58404]
Helicobacter pylori infection induces chronic inflammation and is the strongest known risk factor for gastric cancer. The genomes of H pylori are highly diverse and therefore bacterial virulence factors play an important role in determining the outcome of H pylon infection, in combination with host responses that are augmented by environmental and dietary risk factors. It is important to gain further understanding of the pathogenesis of H pylori infection to develop more effective treatments for this common but deadly malignancy. This review focuses on the specific mechanisms used by H pylori to drive gastric carcinogenesis.
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