期刊
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
卷 40, 期 1, 页码 45-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2010.12.011
关键词
Irritable bowel syndrome; Genetics; Gene; Complex genetic disease
资金
- National Institutes of Health [DK76797]
Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.
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