期刊
GASTROENTEROLOGY
卷 146, 期 6, 页码 1459-1469出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2014.02.001
关键词
Metagenomics; Mycobiome; Virome
资金
- Training Program in Immunology and Immunogenetics [5T32AI007163-35]
- Crohn's & Colitis Foundation of America [3132, 274415]
- Broad Foundation [IBD-0357]
- [R01 AI084887]
- [R01 OD011170]
Advanced sequencing techniques have shown that bacteria are not the only complex and important microbes in the human intestine. Nonbacterial organisms, particularly the virome and the mycobiome, are important regulators of intestinal immunity and inflammation. The virome is mucosal and systemic; it can alter the host response to bacteria and interact with host genes and bacteria to contribute to disease pathogenesis. The human mycobiome is also complex and can contribute to intestinal inflammation. We review what has recently been learned about the nonbacterial and nonarchaeal microbes in the gastrointestinal tract, discussing their potential effects on health and disease and analytical approaches for their study. Studies of associations between the microbiome and intestinal pathology should incorporate kingdom-agnostic approaches if we are to fully understand intestinal health and disease.
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