期刊
GASTROENTEROLOGY
卷 146, 期 6, 页码 1470-1476出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2014.03.001
关键词
Metabolomics; Systems Biology; Data Analysis; Bacteria
资金
- National Institutes of Health Signaling and Cellular Recognition Training Grant [T32 GM08759]
- Canadian Institutes of Health Research [MFE-112991]
- National Research Initiative from the USDA National Institute for Food and Agriculture [2009-55200-05197]
- Howard Hughes Medical Institute
Recent advances that allow us to collect more data on DNA sequences and metabolites have increased our understanding of connections between the intestinal microbiota and metabolites at a whole-systems level. We can also now better study the effects of specific microbes on specific metabolites. Here, we review how the microbiota determines levels of specific metabolites, how the metabolite profile develops in infants, and prospects for assessing a person's physiological state based on their microbes and/or metabolites. Although data acquisition technologies have improved, the computational challenges in integrating data from multiple levels remain formidable; developments in this area will significantly improve our ability to interpret current and future data sets.
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